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What is the best time to take medicine for high blood pressure? However, especially after age 55, many people with high blood pressure don't exhibit this nighttime dip, a condition called non-dipping. When to take medicine : Take at least one blood pressure -lowering medication at bedtime. Drugs called ACE inhibitors and ARBs are the most effective when taken at this time.
Does prazosin cross the blood brain barrier? Prazosin is considered sufficiently lipophilic to cross the blood - brain barrier and antagonize the О± 1 receptors in the CNS, blocking these stress responses. Through this mechanism, prazosin can improve sleep and reduce nightmares associated with PTSD.
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