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When should I take glipizide and metformin? For first-time treatment: Adults: At first, 2.5 milligrams (mg) of glipizide and 250 milligrams (mg) of metformin once a day with a meal. Then, your doctor may increase your dose a little at a time every two weeks until your blood sugar is controlled. Children: Use and dose must be determined by your doctor. Homer Kime looking for glimepiride

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